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Etudes scientifiques
Osteoarthritis Treatment Study
Treatment of knee osteoarthritis with Lyprinol®, lipid extract of the green-lipped mussel – a double-blind placebo-controlled study
CS Lau, PKY Chiu, EMY Chu, IYW Cheng, WM Tang, RYK Man, GM Halpern
Improvement in almost all of the arthritis assessment parameters was observed over six months. Lyprinol was safe and well tolerated with no serious side-effects reported. In conclusion, Lyprinol may be considered a safe option in the treatment of OA.
European Respiratory Studies Journal
Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomised clinical trial
A Emelyanov, G Fedoseev, O Krasnoschekova, A Abulimity, T Trendeleva, PJ Barnes
Selon un rapport publié dans le European Respiratory Journal (2002 ;20 :596-600), la complémentation de l’alimentation par des extraits de moules aux orles vert de Nouvelle Zélande (Perna canaliculus) peut soulager les symptômes et augmenter la capacité pulmonaire chez des patients atteint d’asthme
The Gibson Brief
The treatment of arthritis with a lipid extract of Perna canaliculus: a randomised trial
S.L.M. Gibson, R.G. Gibson
This study concluded that the Lyprinol achieved faster responses in reducing pain, swelling and stiffness and in improving the functional index in rheumatoid arthritis and osteoarthritis.
Allergy and Immunology Study, Part I
Un anti-inflammatoire venu des mers du sud : Lyprinol™
G.-M. Halpern, MD, Phd
Lipides Marins : revue "Nouvelles approches et composition lipidiques de Lyprinol™"
A.J. Sinclair, K.J. Murphy, and D. Li
Comparaison du Lyprinol et d'autres huiles riches en omega-3: l'huile de lin et l'huile de thon. Tant les observations épidémiologiques que les études de populations, ou les recherches fondamentales, suggèrent la possibilité d'influencer la survenue / évolution des maladies cardio-vasculaires, désordres inflammatoires, ou fonctions neurologiques par ingestion des acides gras trouvés dans le Lyprinol®.
Allergy and Immunology Study, Part II
Lyprinol: Anti-Inflammatory And Uterine-Relaxant Activities In Rats, With Special Reference To A Model For Dysmenorrhoea
I.A. Shiels, and M.W. Whitehouse
Lyprinol® exhibits anti-inflammatory activity distinct from that of most NSAIDs, controlling chronic but not acute inflammation. Unlike Cox-1 inhibitors (asprin) it is not gastro-toxic.
Allergy and Immunology Study, Part III
Lyprinol inhibe la production de LTB4 par les monocytes humains
B. Dugas
Cette étude montre que le Lyprinol® aide les patients dans le controle de leur état pro-inflammatoire. En présence de Lyprinol l'hyperactivation de monocytes de patients allergiques est significativement supprimée en controlant la voie de la 5-lipoxygénase.
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Whitehouse Study
Anti-Inflammatory Activity of a Lipid Fraction (Lyprinol®) From the NZ Green-Lipped Mussel
M.W. Whitehouse, T.A. Macrides, N. Kalafatis, W.H. Betts, D.R. Haynes, and J. Broadbent
This study demonstated pronounced antinflammatory efficacy in trials with rats with artificially induced chronic polyarthritis resp. autoimmune arthritis.
OTC Study
Over the counter (OTC) oral remedies for arthritis and rheumatism: how effective are they?
M.W. Whitehouse, M.S. Roberts, and P.M. Brooks
Of 37 herbal formations, the mussel extract used in Lyprinol® was found to be among seven that were as effective as ibuprofen in the anti-arthritic assay.
Hertz Study
The effect of a stabilised oil (Lyprinol®) from green lipped mussel (Perna canaliculus) on pain and Activities of Daily Life in patients with osteoarthritis in knee and/or hip.
Niels Hertz, M.D.
Subjective pain experience with the treatment of Lyprinol capsules resulted in the reduction of pain by more than 50%, with no side effects. The pain relief was accompanied by a considerable improvement in functional ability.
Comparative Biochemistry and Physiology (2007)
Anti-cyclooxygenase effects of lipid extracts from the New Zealand
green-lipped mussel, Perna canaliculus
S. McPhee, L.D. Hodges, P.F.A. Wright, P.M. Wynne, N. Kalafatis,
D.W. Harney, T.A. Macrides
Comparative Biochemistry and Physiology (2008)
The CO2-SFE crude lipid extract and the free fatty acid extract from Perna canaliculus have anti-inflammatory effects on adjuvant-induced arthritis in rats
M. Singh, L.D. Hodges, P.F.A. Wright, D.M.Y. Cheah, P.M. Wynne, N. Kalafatis and T.A. Macrides
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Etudes sur l'homme
Barnes, 2002, Eur. Respir. J.
Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomised clinical trial.
Borland, 1999.
Immunomodulating Effect of Lyprinol in humans vaccinated with live influenza vaccine.
Gibson, 1998, Complementary therapies in Medecine.
The treatment of arthritis with a lipid extract of Perna canaliculus: a randomized trial.
Gibson, 2000, Journal of alternative and complementary medecine. Case Report.
The effect of a lipid extract of the New Zealand Green-Lipped Mussel in three cases of Arthritis.
James 2000, Am. J. Clin. Nutr
Dietary polyunsaturated fatty acids and inflammatory mediator production.
Cho 2002, The Newest Medical Journal.
Clinical Efficacity and Safety of Lyprinol, a patented extract from New Zealand green lipped mussel (Perna canaliculus) in patients with OSTEOARTHRITIS of the Hip and Knee: Multicenter clinical Trial with a 2 months treatment period.
Lau, 2004, Progress in Nutrition.
Treatment of knee osteoarthritis with Lyprinol, lipid extract of the green-lipped mussel - a double blind placebo - controlled study.
Yemelyanov, 2000. Lyprinol Moderate Asthma Trial.
Report about clinical trial with Lyprinol in bronchial asthma.
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Etudes sur animaux
Lee et al., eCAM 2007
Pain controlling and cytokine-regulating effects of Lyprinol, a lipid extract of Perna canaliculus, in a rat adjuvant-induced arthritis model.
Murphy, 2005, Tenikoff et al - J Gastroenterol
Lyprinol (stabilised lipid extract of New Zealand green-lipped mussel): a potential preventive treatment modality for inflammatory bowel disease.
Whitehouse & Rainsford, 1980, Arztnei_ Gastroprotective Orig.
Gastroprotective and anti-inflammatory properties of green lipped mussel (Perna canaliculus) preparartion.
Whitehouse et Shiels, 2000. Allergie et Immunologie.
Lyprinol: activites anti-inflammatoire et utero-relaxantes chez le rat; un modele pour l'etude des dysmenorrhees.
Whitehouse, 1997. Inflammopharmacology.
Anti-inflammatory activity of a lipid fraction (Lyprinol) from the NZ green-lipped mussel.
Whitehouse, 2000. 33rd Internal Report to MAclab: More on Lyprinol.
A pilot study to assess the duration of Lyprinol's efficacy, indicated Lyprinol was effective for at least 3 days after ceasing dosing.
Whitehouse, 2001, Internal report.
Concerning glycogen as a putative pharmaco-active constituent of the NZ green-lipped mussel (GLM).
Whitehouse, 2002. Arthritis & Rheumatism.
High-resolution ultrasound for the study of target joints in rheumatoid arthritis.
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